Associate Professors

Anna Maria CACCURI

Professore Associato SSD: BIO/10 – BiochimicaStanza: E204
Telefono: (+39) 06 7259 6204
Photo of Anna Maria CACCURI

Biographical Info

2014 National Scientific Qualification: Full Professor in Biochemistry (05/E1 – SSD BIO/10).
2001 Associate Professor (Biochemistry SSD: BIO/10) at University of Rome Tor Vergata.
1988 Post-doc fellow in the Department of Human Biological Chemistry and Genetics of the University of Texas, in the Medical Branch of Galveston (U.S.A.) and in the Department of Biochemistry of the University of Oxford (U.K).
1986 Assistant Professor of Biochemistry at the University of Rome Tor Vergata.
1983 Assistant Professor of Biochemistry at the University of Chieti G. D’Annunzio.
1979 Degree in Biological Science (cum laude) at the University of Rome La Sapienza.

RESEARCH ACTIVITY
AMC scientific activity is based on the study of structural, catalytic and physiological properties of glutathione S-transferases. Since 2002 she has been involved in the design, synthesis and study of potent inhibitors of glutathione S-transferases. The new compounds, characterized by a peculiar mechanism of action and promising anticancer properties, have been included in the United States Patent No. US8,796,317 B2 (USE OF 7-NITRO-2,1,3-BENZOXADIAZOLE DERIVATIVES FOR ANTICANCER THERAPY, Caccuri et al.) and in the Italian Patent No 0001412189 (DERIVATI DEL 7-NITRO-2,1,3-BENZOSSADIAZOLO PER TERAPIA ANTITUMORALE, Mai, Caccuri et al). In particular, among the new derivatives, the compound MC3181 is highly effective against human melanoma cell lines harboring the BRAFV600E mutation and against mutated melanoma cells made resistant to the BRAF inhibitor vemurafenib.
She is currently involved in the study of TNF receptor-associated factor 2 (TRAF2), to assess whether its truncated C-terminal domain might play a pivotal role in multivescicular bodies formation and authophagy.

FUNDING RECEIVED:
2005: research contract funded by ISPESL ( Role: PI).
2007-2010 project: “Alliance Against Cancer” funded by the ISS (Role: PI of research unit).
2008 research contract funded by ISPESL ( Role: PI).
2010-2013 project funded by AIRC (Role: PI).
2016-2017 project funded by University of Rome “Tor Vergata” Grant: “Consolidate the Foundations” (Role: PI).
2016-2018 project funded by Italian Ministry of Health (5×1000) and Fondazione Roma (Role PI).
Author of 93 publications on international refereed journals.
Her papers have been cited over 2789 times and her h-index is 31 (ISI & Scopus).

TEACHING ACTIVITY
Enzimology . University of Rome “Tor Vergata” – Master Degree in Chemistry (6 CFU).
Biotechnology and Applied Biochemistry University of Rome “Tor Vergata” – Degree in Chemistry – (6 CFU).
Enzimology University of Rome “Tor Vergata” -Master Degree in Medical Biotechnology – (2 CFU).